Unlocking Reaction Secrets: Using Benchtop NMR to Solve the Biginelli Condensation Mystery

Join us as we explore how scientists used cutting-edge benchtop 19F Nuclear Magnetic Resonance (NMR) spectroscopy to unravel the complexities of the Biginelli condensation, a key reaction for creating new drugs.
Chen, Rosie; Singh, Pratyush; Su, Sarah; Kocalar, Selin; Wang, Xina; Mandava, Neha; Venkatesan, Srishti; Ferguson, Adrienne; Rao, Aishi; Le, Emma; Rojas, Casey; Njoo, Edward. “Benchtop 19F Nuclear Magnetic Resonance (NMR) Spectroscopy Provides Mechanistic Insight into the Biginelli Condensation towards the Chemical Synthesis of Novel Trifluorinated Dihydro- and Tetrahydropyrimidinones as Antiproliferative Agents.” ACS Omega 2023. DOI: https://doi.org/10.1021/acsomega.3c00290